Minnesotans are amoung the most prolific inventors in the country. A review of filings with the U-S Patent and Trademark office from 1990 to 1999 ranked Rochester 3rd and the Twin Cities 10th in number of patents for every 100-thousand residents. Minnesota was the only state to place two metro areas in the top ten. The review was conducted by an online newsletter called Demographics Daily. Mike Moore is the director of health technologies at the University of Minnesota. He says both the Mayo Clinic and the University of Minnesota have large research budgets that drive innovation: